Deep surgical site infections following double-dose perioperative antibiotic prophylaxis in adult obese orthopedic patients
نویسندگان
چکیده
BackgroundObesity is a risk factor for surgical site infections (SSI). Based on retrospective comparisons and pharmacology, many orthopedic centers have adopted weight- or body mass index (BMI)-related antibiotic prophylaxis.MethodsDouble-dose prophylaxis was introduced in March 2017 patients weighting >80 kg. The period April 2014 to (‘before’) compared the June 2019 (‘after’) regarding impact deep SSIs.ResultsA total of 9318 surgeries ‘before’ were 7455 interventions ‘after’ introduction double-dose prophylaxis. Baseline demographic characteristics (age, sex, BMI, American Society Anesthesiologists score, duration surgery) similar. In ‘after’, 3088 cases (3088/16 773; 18%) received Overall, 82 SSIs observed (0.5%). pathogens resistant standard cefuroxime 30 (30/82; 37%). Excluding these prophylaxis-resistant all five hematogenous SSIs, remaining 47 (57%) could been prevented by preceding Double-dosing parenteral from 1.5 g 3.0 obese did not reduce (hazard ratio 0.7, 95% confidence interval 0.3–1.6). direct group comparison among kg, equally failed alter SSI 726 non-infections vs 8/47 despite prophylaxis; Chi-square test, P = 0.78).ConclusionsIn this single-center before-and-after study with almost 17 000 adult patients, systemic doubling perioperative clinically overall risk.
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2021
ISSN: ['1878-3511', '1201-9712']
DOI: https://doi.org/10.1016/j.ijid.2021.06.008